T cell-derived migration-inhibitory factor and colony-stimulating factor share common structural elements

T cell-derived migration-inhibitory factor and colony-stimulating factor share common structural elements.

Migration-inhibitory factor (MIF) is a lymphokine that acts to localize mononuclear phagocytes (monocytes and macrophages) and perhaps to activate them. Mo cells are a human T cell leukemia virus II-infected T cell line previously shown to secrete large quantities of MIF upon stimulation with phytohemagglutinin and phorbol myristate acetate. MIF was purified from Mo cell-conditioned medium by g...

T cell functions in granulocyteymacrophage colony-stimulating factor deficient mice

Immunological functions were analyzed in mice lacking granulocyteymacrophage colony-stimulating factor (GM-CSF). The response of splenic T cells to alloantigens, anti-mouse CD3 mAb, interleukin 2 (IL-2), or concanavalin A was comparable in GM-CSF 1y1 and GM-CSF 2y2 mice. To investigate the responses of CD81 and CD41 T cells against exogenous antigens, mice were immunized with ovalbumin peptide ...

STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR

In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...

Granulocyte colony-stimulating factor.

In the background section of their abstract, Woei-Cherng Shyu and associates state that because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory and neuroprotective properties and the capacity to mobilize stem cells, it has the potential to be used in treatment of stroke. However, there are limited data about the effects of G-CSF on hemostasis. It has been suggested that G-CS...

Macrophage Colony-Stimulating Factor